Research Fellow (Structural / Chemical Biology), Medicine, Medical Sciences & Nutrition at the University of Aberdeen | EMBRC

Research Fellow (Structural / Chemical Biology), Medicine, Medical Sciences & Nutrition at the University of Aberdeen

2019.11.15

Research Fellow (Structural / Chemical Biology), Medicine, Medical Sciences & Nutrition at the University of Aberdeen

This post is based in the Institute of Medical Sciences at the University of Aberdeen. The successful applicant will join a group led by Dr Wael Houssen focused on developing enzymatic tools to generate bioactive cell-permeable peptides.

School/Section: Medicine, Medical Sciences & Nutrition Division: Institute of Medical Sciences
Staff Category: Research
Position Type: Full Time

Grade: Grade 6
Salary: £33,797 - £35,844 

Ref No: IMS178R
Closing Date: 22-NOV-2019

Job Description

There is a growing evidence that cyclic and stapled peptides can modulate therapeutic targets with extended binding sites e.g. protein-protein interactions (PPIs). These targets are known to be challenging for traditional small molecule drugs while biological drugs can only modulate extracellular PPIs. The prospect for cyclic peptides rests then on the premise they can hit intracellular PPIs that are implicated in many critical diseases e.g. cancer and autoimmune disorders. However, the majority of these compounds have negligible cellular permeability and poor oral bioavailability. Several approaches have been proposed to modify peptides for enhanced cellular permeability. However, these approaches entail total re-synthesis of the molecule which is time consuming and inefficient. In addition, some modifications that improve permeability have negative impact on biological activity.

You must have a PhD in structural biology, chemical biology, synthetic biology, biochemistry or related subjects and specific expertise in X-ray protein crystallography. Experience in solid phase peptide synthesis will be an advantage but training is available if needed.

Salary will be at the appropriate point on the Grade 6 salary scale and negotiable with placement according to qualifications and experience.

This post will be available until 31 July 2023.
Any appointment will be made subject to satisfactory references and a 12 monthprobation period.

For further information on various staff benefits and policies please visit www.abdn.ac.uk/staffnet/working-here

Should you require a visa to undertake paid employment in the UK you will be required to fulfil the minimum points criteria to be granted a Certificate of Sponsorship and Tier 2 visa. As appropriate, at the time an offer of appointment is made you will be asked to demonstrate that you fulfil the criteria in respect of financial maintenance and competency in English. Please do not hesitate to contact Grant Rae, HR Adviser on +44 (0)1224 437068 or email grant.rae@abdn.ac.uk for further information.

The closing date for receipt of applications is 22 November 2019 Should you wish to make an informal enquiry please contact:

Dr. Wael Houssen, Senior Research Fellow
01224 437564 

Please do not send application forms or CVs to Dr Wael Houssen. Please quote reference number IMS178R on all correspondence and apply on the University Job Portal

The School of Medicine, Medical Sciences and Nutrition welcomes a diverse working environment and recognises the benefits this can bring. The School is keen to receive applications from individuals from across all of the equality protected characteristics (race, gender, disability, gender reassignment, age, sexual orientation, religion/belief, pregnancy/maternity, marriage/civil partnership).

The University supports opportunities for flexible working for a range of reasons and has policies in place to facilitate this. The policies can be found here: https://www.abdn.ac.uk/staffnet/working-here/flexible-working--5607.php

The University’s commitment to gender equality has been recognised through the achievement of an Athena SWAN Bronze award. The University is also a Stonewall Diversity Champion to further LGBT equality and a Disability Committed Employer recognising our commitment to supporting disabled staff and students. https://www.abdn.ac.uk/staffnet/governance/equality-and-diversity-277.php

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